Journal: Current Infectious Disease Reports

Article Title: Syndromic Multiplex Polymerase Chain Reaction (mPCR) Testing and Antimicrobial Stewardship: Current Practice and Future Directions

doi: 10.1007/s11908-021-00748-z

Figure Lengend Snippet: Multiplex PCR and antimicrobial and diagnostic stewardship: key findings

Article Snippet: Central nervous system mPCR panel , Dack et al. [ ], Chang et al. [ ], Radmard et al. [ ], Mina et al. [ ] , • One mPCR panel, the BioFire FilmArray meningitis-encephalitis panel, is U.S. FDA approved • CNS mPCR is associated with improved turnaround time (over traditional methods) • mPCR may have suboptimal sensitivity for Cryptococcus compared to traditional diagnostic testing; this has important implications for testing and clinical management • Positive test results for specific viruses have to be interpreted in context (as these may represent systemic reactivation and not active infection) • The optimal role of Antimicrobial Stewardship Programs in mPCR test review and intervention needs to be defined • CNS mPCR is promising but more research is needed.

Techniques: Multiplex Assay, Diagnostic Assay, Refining, Infection

Journal: Journal of Infection and Chemotherapy

Article Title: The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan ☆

doi: 10.1016/j.jiac.2019.07.014

Figure Lengend Snippet: Background.

Article Snippet: We replaced rapid antigen tests with the mPCR respiratory panel (FilmArray®; Biofire, Utah, USA) as a microbiological diagnostic test for pediatric respiratory infections admitted since March 26, 2018.

Techniques: Biomarker Discovery

Journal: Journal of Infection and Chemotherapy

Article Title: The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan ☆

doi: 10.1016/j.jiac.2019.07.014

Figure Lengend Snippet: mPCR group chart.

Article Snippet: We replaced rapid antigen tests with the mPCR respiratory panel (FilmArray®; Biofire, Utah, USA) as a microbiological diagnostic test for pediatric respiratory infections admitted since March 26, 2018.

Techniques:

Journal: Journal of Infection and Chemotherapy

Article Title: The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan ☆

doi: 10.1016/j.jiac.2019.07.014

Figure Lengend Snippet: Outcomes.

Article Snippet: We replaced rapid antigen tests with the mPCR respiratory panel (FilmArray®; Biofire, Utah, USA) as a microbiological diagnostic test for pediatric respiratory infections admitted since March 26, 2018.

Techniques:

Journal: Journal of Infection and Chemotherapy

Article Title: The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan ☆

doi: 10.1016/j.jiac.2019.07.014

Figure Lengend Snippet: The number of pathogen detections by mPCR. Adeno; Adenovirus, Corona; Coronavirus HKU1, NL63, 229E or OC43, hMPV; human metapneumovirus, Rhino/Entero; Rhinovirus or Enterovirus, Flu; Influenza virus A, A H1, A H3, A H1-2009 or B, RS; Respiratory syncytial virus, Para; Parainfluenza virus 1, 2, 3 or 4, Mycoplasma; Mycoplasma Pneumoniae , Chlamydia; Chlamydia Pneumoniae , Pertussis; Bordetella pertussis .

Article Snippet: We replaced rapid antigen tests with the mPCR respiratory panel (FilmArray®; Biofire, Utah, USA) as a microbiological diagnostic test for pediatric respiratory infections admitted since March 26, 2018.

Techniques: Virus

Journal: Clinical Microbiology and Infection

Article Title: Rapid diagnostic tests for infectious diseases in the emergency department

doi: 10.1016/j.cmi.2020.02.024

Figure Lengend Snippet: Nonexhaustive list of commercially available US Food and Drug Administration– and Conformité Européenne–approved point-of-care tests in infectious diseases classified by syndrome or disease of interest

Article Snippet: , mPCR in ED vs. usual tests in central laboratory , FilmArray (BioFire, bioMérieux) , Adults (720) , SSPS , mPCR in ED decreases the duration of antibiotic use (from 6.5 to 2.9 days, p 0.0009), the hospital length of stay (from 6.8 to 5.7 days, p 0.004) , [ ] .

Techniques: Surround Optical-fiber Immunoassay, DNA Amplification, Virus, Clinical Proteomics, Stripping Membranes

Journal: Clinical Microbiology and Infection

Article Title: Rapid diagnostic tests for infectious diseases in the emergency department

doi: 10.1016/j.cmi.2020.02.024

Figure Lengend Snippet: Clinical studies evaluating clinical impact of RDT use in ED

Article Snippet: , mPCR in ED vs. usual tests in central laboratory , FilmArray (BioFire, bioMérieux) , Adults (720) , SSPS , mPCR in ED decreases the duration of antibiotic use (from 6.5 to 2.9 days, p 0.0009), the hospital length of stay (from 6.8 to 5.7 days, p 0.004) , [ ] .

Techniques: Infection, Biomarker Discovery, Modification, Diagnostic Assay

Journal: Antibiotics

Article Title: Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children

doi: 10.3390/antibiotics10030283

Figure Lengend Snippet: Comparison of antibiotic use and hospital stay according to mPCR test and period.

Article Snippet: From July 2016 to July 2018 (periods II and III), newly adopted mPCR testing was performed on nasopharyngeal swabs by using the FA-RP (BioFire Diagnostics, Inc., Salt Lake City, UT, USA).

Techniques: Comparison